Home Single Peptide Dosages Survodutide (10 mg Vial) Dosage Protocol

Survodutide (10 mg Vial) Dosage Protocol

Survodutide Dosage Chart

Survodutide is dosed at 600 mcg–6 mg weekly via subcutaneous injection in educational protocols. A 10 mg vial reconstituted with bacteriostatic water yields about 5 mg/mL. This information is for research and educational use only.

  • Reconstitute: Add 2.0 mL bacteriostatic water → 5 mg/mL (5000 mcg/mL) concentration.
  • Typical weekly range: 0.6–6.0 mg once weekly (gradual titration over 10–12 weeks).
  • Easy measuring: At 5 mg/mL, 1 unit = 0.01 mL = 50 mcg on a U‑100 insulin syringe.
  • Storage: Lyophilized: freeze at ≤−20 °C (≤−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); protect from light.
Survodutide 10mg vial - Survodutide dosage protocol

Survodutide (BI 456906) is an investigational dual GLP‑1/glucagon receptor agonist under development for obesity and metabolic liver disease[1][2]. In phase 2 trials, once‑weekly subcutaneous dosing (0.6–4.8 mg) produced dose‑dependent weight loss of 12.5–14.9% versus placebo over 46 weeks[1]. This educational protocol presents a once‑weekly subcutaneous titration approach using a practical dilution for clear insulin‑syringe measurements.

Dosing & Reconstitution Guide

Educational guide for reconstitution and weekly dosing

Standard / Gradual Titration (2 mL = 5 mg/mL)

Week Weekly Dose (mg) Weekly Dose (mcg) Units (mL)
Weeks 1–2 0.6 mg 600 mcg 12 units (0.12 mL)
Weeks 3–4 1.2 mg 1200 mcg 24 units (0.24 mL)
Weeks 5–6 1.8 mg 1800 mcg 36 units (0.36 mL)
Weeks 7–8 2.4 mg 2400 mcg 48 units (0.48 mL)
Weeks 9–10 3.6 mg 3600 mcg 72 units (0.72 mL)
Weeks 11–12 4.8 mg 4800 mcg 96 units (0.96 mL)
Week 13+ 6.0 mg 6000 mcg 120 units (1.20 mL)*

Route & Frequency: Subcutaneous injection once weekly (all clinical trials used weekly dosing)[1][2].

*Note: The 6.0 mg maintenance dose (120 units / 1.20 mL) exceeds a standard 100‑unit (1 mL) insulin syringe. Use a 1 mL or 3 mL Luer‑lock syringe with appropriate needle, or administer as two separate injections.

Reconstitution Steps

  1. Draw 2.0 mL bacteriostatic water with a sterile syringe.
  2. Inject slowly down the vial wall; avoid foaming.
  3. Gently swirl/roll until dissolved (do not shake).
  4. Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
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Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.

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Supplies Needed

Plan based on an 8–16 week weekly protocol with gradual titration.

  • Peptide Vials (Survodutide, 10 mg each):
    • 8 weeks ≈ 2 vials (~17 mg total)
    • 12 weeks ≈ 4 vials (~39 mg total)
    • 16 weeks ≈ 7 vials (~63 mg total)
  • Insulin Syringes (U‑100) or 1 mL Luer‑lock Syringes:
    • Per week: 1 syringe (once weekly)
    • 8 weeks: 8 syringes
    • 12 weeks: 12 syringes
    • 16 weeks: 16 syringes
  • Bacteriostatic Water (10 mL bottles): Use 2.0 mL per vial for reconstitution.
    • 8 weeks (2 vials): 4 mL → 1 × 10 mL bottle
    • 12 weeks (4 vials): 8 mL → 1 × 10 mL bottle
    • 16 weeks (7 vials): 14 mL → 2 × 10 mL bottles
  • Alcohol Swabs: One for the vial stopper + one for the injection site each week.
    • Per week: 2 swabs
    • 8 weeks: 16 swabs
    • 12 weeks: 24 swabs
    • 16 weeks: 32 swabs → recommend 1 × 100‑count box